| ITF W25 - Hamborg | 01/12 11:30 | 25 | [371] Marina B Ribera v Despina Papamichail [278] | 6-2,6-7,6-1 | |
| WTA - Abu Dhabi | 01/07 13:35 | 24 | [278] Despina Papamichail v Karolina Pliskova [6] | 2-6,6-7 | |
| WTA - Abu Dhabi | 01/06 06:00 | 19 | [278] Despina Papamichail v Zhaoxuan Yang [55] | 2-6,2-6 | |
| WTA - Abu Dhabi | 01/05 08:05 | 64 | [278] Despina Papamichail v Federica Di Sarra [320] | 2-6,7-5,6-1 | |
| ITF W25 - LPD Gran Canaria | 11/18 10:00 | 25 | [287] Amandine Hesse v Despina Papamichail [276] | 3-6,6-4,6-3 | |
| ITF W25 - Istanbul | 10/28 07:00 | 26 | [277] Despina Papamichail v Katarina Zavatska [116] | 2-6,5-7 | |
| ITF W25 - Istanbul | 10/27 08:50 | 25 | Despina Papamichail v Doga Akyurek | 6-3,6-2 | |
| ITF W25 - Istanbul | 10/26 07:00 | 54 | [277] Despina Papamichail v Ekaterina Kazionova [423] | 6-3,3-6,10-4 | |
| ITF W25 - Istanbul | 10/25 07:00 | 54 | Despina Papamichail v Betina Tokac | 6-1,6-1 | |
| ITF W25 - Reims | 10/18 10:15 | 54 | [278] Despina Papamichail v Francesca Jones [258] | 6-7,6-4,5-10 | |
| ITF W25 - Cherbourg | 10/11 15:40 | 54 | Lucie Wargnier v Despina Papamichail | 6-4,2-6,11-9 | |
| ITF W25 - Olimpia | 03/10 19:00 | 25 | [320] Francesca Jones v Despina Papamichail [264] | 6-2,6-1 | |
| ITF W25 - Antalya | 03/06 07:00 | 27 | [263] Despina Papamichail v Amina Anshba [352] | 3-6,1-6 | |
| ITF W25 - Antalya | 03/05 06:50 | 26 | [263] Despina Papamichail v Tena Lukas [262] | 2-6,6-2,6-3 | |
| ITF W25 - Antalya | 03/04 07:00 | 25 | Despina Papamichail v Ipek Oz | 7-6,6-2 | |
| ITF W60 - Cairo | 02/17 11:25 | 54 | [260] Despina Papamichail v Yidi Yang [461] | 3-6,6-2,8-10 | |
| ITF W60 - Cairo | 02/16 08:55 | 54 | Despina Papamichail v Merna Refaat | 6-0,6-2 | |
| ITF W25 - Trnava | 02/12 16:40 | 25 | [259] Despina Papamichail v Anna Kubareva [479] | 2-6,4-6 | |
| Fed Cup 2020 | 02/08 12:05 | - | [143] Viktoriya Tomova v Despina Papamichail [258] | 6-2,6-4 | |
| Fed Cup 2020 | 02/06 15:25 | 2 | [221] Julia Grabher v Despina Papamichail [258] | 1-6,6-4,7-5 | |
| Fed Cup 2020 | 02/05 16:30 | 1 | [22] Anett Kontaveit v Despina Papamichail [258] | 3-6,6-3,6-0 | |
| ITF W25 - Pune | 12/10 07:00 | 25 | [471] Shalimar Talbi v Despina Papamichail [267] | 6-4,3-6,6-1 | |
| ITF W25 - Solapur | 12/04 10:15 | 25 | Despina Papamichail v Emma Raducanu | 2-6,1-6 | |
| ITF W25 - Solarino | 11/27 09:00 | 25 | [286] Lara Salden v Despina Papamichail [263] | 3-6,6-4,6-1 | |
| ITF W25 - Naples | 11/20 14:00 | 25 | [311] Gabriela Talaba v Despina Papamichail [263] | 6-3,6-7,6-2 | |
| ITF - W25 Orlando | 11/13 15:00 | 25 | Despina Papamichail v Maria Mateas | 3-6,6-7 | |
| ITF W60 Colina | 11/05 18:20 | 25 | [407] Carolina Meligeni Rodrigues Alves v Despina Papamichail [260] | 4-6,7-5,6-3 | |
| ITF W60 Asuncion | 10/30 19:25 | 25 | Barbara Gatica v Despina Papamichail | 6-3,6-1 | |
| ITF W100 Szekesfehervar | 10/22 08:55 | 54 | [263] Despina Papamichail v Marie Benoit [306] | 6-2,3-6,5-10 | |
| ITF W100 Szekesfehervar | 10/21 13:55 | 54 | [263] Despina Papamichail v Vivien Juhaszova [325] | 5-7,6-3,10-8 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.