| NCAAF | 09/18 17:00 | 1 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 | |
| NCAAF | 09/11 23:30 | 1 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 | |
| NCAAF | 09/04 16:00 | 1 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 | |
| NCAAF | 11/16 18:00 | 1 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 | |
| NCAAF | 11/09 16:00 | 1 | Virginia Wise Highland Cavaliers v Catawba Indians | W | 21-14 | |
| NCAAF | 11/02 18:00 | 1 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 | |
| NCAAF | 10/26 22:00 | 1 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 | |
| NCAAF | 10/19 17:00 | 1 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 19-21 | |
| NCAAF | 10/12 20:00 | 1 | Newberry Wolves v Virginia Wise Highland Cavaliers | L | 30-7 | |
| NCAAF | 10/05 18:00 | 1 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 63-6 | |
| NCAAF | 09/28 17:00 | 1 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 42-7 | |
| NCAAF | 09/21 16:00 | 1 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 14-21 | |
| NCAAF | 09/14 23:00 | 1 | Tennessee Tech v Virginia Wise Highland Cavaliers | L | 31-14 | |
| NCAAF | 09/07 16:00 | 1 | Virginia Wise Highland Cavaliers v Chowan Hawks | W | 40-22 | |
| NCAAF | 11/10 17:00 | 1 | Shepherd Rams v Virginia Wise Highland Cavaliers | W | 16-21 | |
| NCAAF | 11/03 16:00 | 1 | Virginia Wise Highland Cavaliers v Notre Dame Falcons | L | 17-25 | |
| NCAAF | 10/20 17:00 | 1 | University of Charleston Golden Eagles v Virginia Wise Highland Cavaliers | L | 24-10 | |
| NCAAF | 10/13 18:00 | 1 | Virginia Wise Highland Cavaliers v W. Virginia Bobcats | W | 35-14 | |
| NCAAF | 10/06 17:00 | 1 | Urbana Blue Knights v Virginia Wise Highland Cavaliers | W | 0-17 | |
| NCAAF | 09/29 18:00 | 1 | Virginia Wise Highland Cavaliers v Fairmont State | L | 6-24 | |
| NCAAF | 09/22 17:00 | 1 | West Liberty Hilltoppers v Virginia Wise Highland Cavaliers | L | 23-17 | |
| NCAAF | 09/15 17:00 | 1 | Virginia Wise Highland Cavaliers v Concord University Mountain Lions | W | 35-20 | |
| NCAAF | 09/08 16:00 | 1 | West Virginia State Yellow Jackets v Virginia Wise Highland Cavaliers | L | 33-12 | |
| NCAAF | 08/30 23:00 | 1 | Virginia Wise Highland Cavaliers v Glenville State Pioneers | L | 7-17 |