[12] Santa Clara 0-5 Benfica [1] 2021-09-11 17:00
Stadium: Estadio de Sao Miguel Round: 5
Referee: Rui Manuel Gomes da Costa Home Manager: Daniel Ramos Away Manager: Jorge Jesus
Head to Head
| Portugal - Primeira Liga | 2021/04/26 18:00 | Benfica v Santa Clara | L | 2-1 |
| Portugal - Primeira Liga | 2021/01/04 17:00 | Santa Clara v Benfica | D | 1-1 |
| Portugal - Primeira Liga | 2020/06/23 18:15 | Benfica v Santa Clara | W | 3-4 |
| Portugal - Primeira Liga | 2019/11/09 18:00 | Santa Clara v Benfica | L | 1-2 |
| Portugal - Primeira Liga | 2019/05/18 17:30 | Benfica v Santa Clara | L | 4-1 |
| Portugal - Primeira Liga | 2019/01/11 19:00 | Santa Clara v Benfica | L | 0-2 |