Stadium: Hanson Field Round: 1
Home Manager: Myers Hendrickson Away Manager: Nick Hill
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | W | 7-30 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2019/11/16 19:00 | SO Illinois v Western Illinois | W | 45-21 |
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | L | 34-31 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | L | 28-14 |
| NCAAF | 2023/10/21 19:00 | South Dakota State v SO Illinois | L | 17-10 |
| NCAAF | 2023/10/14 19:00 | SO Illinois v Murray State | W | 27-6 |
| NCAAF | 2023/10/07 22:00 | SO Illinois v Youngstown State | L | 3-31 |
| NCAAF | 2023/09/30 21:00 | Missouri St v SO Illinois | W | 20-33 |
| NCAAF | 2023/09/16 23:00 | SO Illinois v SE Missouri St | W | 26-25 |
| NCAAF | 2023/09/09 19:30 | SO Illinois v Northern Illinois | W | 14-11 |
| NCAAF | 2023/09/02 23:00 | Austin Peay v SO Illinois | W | 23-49 |
| NCAAF | 2022/11/19 17:00 | SO Illinois v Youngstown State | L | 21-28 |
| NCAAF | 2023/10/21 19:30 | Western Illinois v North Dakota State | L | 7-52 |
| NCAAF | 2023/10/14 20:00 | Missouri St v Western Illinois | L | 48-7 |
| NCAAF | 2023/10/07 18:00 | Western Illinois v North Dakota | L | 10-49 |
| NCAAF | 2023/09/24 00:00 | Western Illinois v Southern Utah | L | 17-37 |
| NCAAF | 2023/09/16 23:00 | Lindenwood v Western Illinois | L | 43-40 |
| NCAAF | 2023/09/09 20:00 | Illinois State v Western Illinois | L | 34-18 |
| NCAAF | 2023/09/03 01:00 | Western Illinois v New Mexico State | L | 21-58 |
| NCAAF | 2022/11/19 17:00 | Western Illinois v Illinois State | L | 13-20 |