Stadium: Buccaneer Field Round: 1
| NCAAF | 2022/11/12 17:00 | Charleston Southern v North Carolina A&T | L | 10-20 |
| NCAAF | 2022/11/05 16:00 | Robert Morris v Charleston Southern | W | 21-34 |
| NCAAF | 2022/10/29 17:00 | Charleston Southern v Kennesaw State | L | 20-30 |
| NCAAF | 2022/10/22 22:00 | Gardner Webb v Charleston Southern | L | 28-14 |
| NCAAF | 2022/10/15 20:00 | Charleston Southern v Bryant | W | 24-23 |
| NCAAF | 2022/10/08 20:00 | Charleston Southern v Campbell | L | 28-34 |
| NCAAF | 2022/09/24 16:00 | Furman v Charleston Southern | L | 24-19 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | L | 17-40 |
| NCAAF | 2022/11/05 16:00 | Shorter Hawks v North Greenville Crusaders | L | 31-14 |
| NCAAF | 2022/10/29 19:00 | North Greenville Crusaders v Valdosta State | L | 37-58 |
| NCAAF | 2022/10/22 21:00 | West Alabama Tigers v North Greenville Crusaders | W | 33-34 |
| NCAAF | 2022/10/15 17:00 | North Greenville Crusaders v West Georgia Wolves | L | 35-38 |
| NCAAF | 2022/10/08 17:00 | North Greenville Crusaders v Delta State | L | 14-47 |
| NCAAF | 2022/10/01 21:00 | West Florida v North Greenville Crusaders | L | 34-31 |
| NCAAF | 2022/09/24 17:00 | North Greenville Crusaders v Findlay Oilers | W | 34-27 |
| NCAAF | 2022/09/17 19:00 | Mississippi College Choctaws v North Greenville Crusaders | W | 19-41 |