[3] Bayer Leverkusen 0-3 FC Porto [4] 2022-10-12 19:00
Stadium: BayArena Round: 4
Referee: Istvan Kovacs Home Manager: Gerardo Seoane Away Manager: Sergio Conceicao
Head to Head
| UEFA Champions League | 2022/10/04 19:00 | FC Porto v Bayer Leverkusen | L | 2-0 |
| UEFA Europa League | 2020/02/27 17:55 | FC Porto v Bayer Leverkusen | W | 1-3 |
| UEFA Europa League | 2020/02/20 20:00 | Bayer Leverkusen v FC Porto | W | 2-1 |
| Venskabskampe for klubhold | 2016/07/27 16:00 | Bayer Leverkusen v FC Porto | D | 1-1 |
Home History
| Tyskland - Bundesliga | 2022/10/08 13:30 | Bayer Leverkusen v Schalke 04 | W | 4-0 |
| UEFA Champions League | 2022/10/04 19:00 | FC Porto v Bayer Leverkusen | L | 2-0 |
| Tyskland - Bundesliga | 2022/09/30 18:30 | Bayern München v Bayer Leverkusen | L | 4-0 |
| Tyskland - Bundesliga | 2022/09/17 13:30 | Bayer Leverkusen v Werder Bremen | D | 1-1 |
| UEFA Champions League | 2022/09/13 19:00 | Bayer Leverkusen v Atletico Madrid | W | 2-0 |
| Tyskland - Bundesliga | 2022/09/10 13:30 | Hertha Berlin v Bayer Leverkusen | D | 2-2 |
| UEFA Champions League | 2022/09/07 19:00 | Club Brugge v Bayer Leverkusen | L | 1-0 |
| Tyskland - Bundesliga | 2022/09/03 13:30 | Bayer Leverkusen v SC Freiburg | L | 2-3 |
Away History
| Portugal - Primeira Liga | 2022/10/08 17:00 | Portimonense v FC Porto | W | 0-2 |
| UEFA Champions League | 2022/10/04 19:00 | FC Porto v Bayer Leverkusen | W | 2-0 |
| Portugal - Primeira Liga | 2022/09/30 20:15 | FC Porto v Braga | W | 4-1 |
| Portugal - Primeira Liga | 2022/09/17 17:00 | Estoril v FC Porto | D | 1-1 |
| UEFA Champions League | 2022/09/13 19:00 | FC Porto v Club Brugge | L | 0-4 |
| Portugal - Primeira Liga | 2022/09/10 19:30 | FC Porto v Chaves | W | 3-0 |
| UEFA Champions League | 2022/09/07 19:00 | Atletico Madrid v FC Porto | L | 2-1 |
| Portugal - Primeira Liga | 2022/09/03 19:30 | Gil Vicente v FC Porto | W | 0-2 |