Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Bubba McDowell Away Manager: Terry Sims
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | W | 45-35 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | L | 48-8 |
| NCAAF | 2022/10/08 22:00 | Bethune Cookman v Tennessee State | L | 17-41 |
| NCAAF | 2022/10/01 19:00 | Bethune Cookman v Alabama | L | 27-35 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | W | 19-36 |
| NCAAF | 2022/09/10 20:00 | South Carolina State v Bethune Cookman | L | 33-9 |
| NCAAF | 2022/09/03 19:30 | Bethune Cookman v Miami Florida | L | 13-70 |
| NCAAF | 2021/11/20 20:30 | Florida A&M v Bethune Cookman | L | 46-21 |
| NCAAF | 2022/10/22 21:00 | Prairie View v Lamar | W | 54-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | L | 45-13 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | W | 34-14 |
| NCAAF | 2022/09/24 22:00 | Prairie View v Alabama State | W | 25-15 |
| NCAAF | 2022/09/17 23:00 | Incarnate Word v Prairie View | L | 31-14 |
| NCAAF | 2022/09/11 00:00 | Prairie View v Abilene Christian | L | 13-21 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | W | 23-40 |
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | L | 10-27 |