[150] Vasek Pospisil 4-6,4-6 John Isner [26] 2022-02-12 01:00
Stadium: Stadium Round: 27 Ground: Hardcourt indoor
Head to Head
| ATP - Atlanta | 2017/07/26 22:40 | Vasek Pospisil v John Isner | 3-6,4-6 |
| ATP - Montreal | 2015/08/12 22:55 | Vasek Pospisil v John Isner | 6-7,6-4,3-6 |
| ATP - Washington | 2015/08/07 02:50 | Vasek Pospisil v John Isner | 4-6,6-7 |
| Hopman Cup | 2015/01/06 10:45 | Vasek Pospisil v John Isner | 6-3,7-6 |
Home History
| ATP - Dallas | 2022/02/10 18:00 | Jurij Rodionov v Vasek Pospisil | 7-6,6-7,2-6 |
| ATP - Dallas | 2022/02/09 01:00 | Vasek Pospisil v Caleb Chakravarthi | 6-1,6-0 |
| ATP - Dallas | 2022/02/07 18:00 | Vasek Pospisil v Christopher Eubanks | 6-3,7-6 |
| ATP - Dallas | 2022/02/06 19:35 | Vasek Pospisil v Yasutaka Uchiyama | 7-5,6-3 |
| Challenger - Quimper | 2022/01/30 14:00 | Gregoire Barrere v Vasek Pospisil | 4-6,6-3,1-6 |
| Challenger - Quimper | 2022/01/29 15:45 | Vasek Pospisil v Hiroki Moriya | 6-2,6-3 |
| Challenger - Quimper | 2022/01/28 13:00 | Vasek Pospisil v Tim Van Rijthoven | 7-6,6-4 |
| Challenger - Quimper | 2022/01/27 17:00 | Vasek Pospisil v Lukas Lacko | 6-4,6-3 |
Away History
| ATP - Dallas | 2022/02/10 01:00 | Kevin Anderson v John Isner | 6-7,7-6,6-7 |
| Australian Open | 2022/01/18 03:15 | Maxime Cressy v John Isner | 7-6,7-5,6-7,6-7,6-4 |
| ATP - Adelaide 2 | 2022/01/12 04:30 | Thanasi Kokkinakis v John Isner | 6-7,7-6,7-6 |
| ATP Cup | 2022/01/05 23:00 | Daniel Evans v John Isner | 6-4,7-6 |
| ATP Cup | 2022/01/03 23:00 | Jan-Lennard Struff v John Isner | 7-6,4-6,7-5 |
| ATP Cup | 2022/01/01 23:00 | Brayden Schnur v John Isner | 1-6,3-6 |
| Davis Cup | 2021/11/28 19:10 | John Isner v Daniel Elahi Galan | 3-6,6-3,6-7 |
| Davis Cup | 2021/11/26 16:45 | John Isner v Jannik Sinner | 2-6,0-6 |