Stadium: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Tim Rebowe
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/04/10 20:00 | SE Louisiana v Nicholls State | L | 52-45 |
| NCAAF | 2019/11/22 00:00 | Nicholls State v SE Louisiana | W | 28-27 |
| NCAAF FCS | 2018/11/16 00:00 | SE Louisiana v Nicholls State | W | 0-44 |
| NCAAF | 2017/11/17 00:00 | SE Louisiana v Nicholls State | L | 21-17 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | L | 27-23 |
| NCAAF | 2021/11/06 17:00 | Nicholls State v McNeese State | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | Northwestern State v Nicholls State | W | 21-42 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | W | 44-14 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | W | 14-31 |
| NCAAF | 2021/11/14 00:00 | Northwestern State v SE Louisiana | W | 28-56 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana v Incarnate Word | L | 52-55 |
| NCAAF | 2021/10/30 23:00 | McNeese State v SE Louisiana | W | 20-23 |
| NCAAF | 2021/10/23 20:00 | SE Louisiana v Northwestern State | W | 51-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | W | 24-61 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | W | 58-48 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | W | 38-35 |
| NCAAF | 2021/09/18 16:00 | SE Louisiana v Central Connecticut | W | 56-10 |