Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager: Chris Hatcher
| NCAAF FCS | 2018/11/10 19:00 | Samford v The Citadel | L | 27-42 |
| NCAAF FCS | 2018/11/03 19:00 | Wofford v Samford | W | 20-35 |
| NCAAF | 2018/10/20 18:00 | Furman v Samford | W | 25-38 |
| NCAAF | 2018/10/13 19:00 | VMI v Samford | W | 22-73 |
| NCAAF | 2018/10/06 17:30 | Western Carolina v Samford | W | 28-66 |
| NCAAF | 2018/09/29 22:00 | Samford v Kennesaw State | L | 10-24 |
| NCAAF | 2018/09/22 23:00 | Samford v Tennessee Chattanooga | L | 20-27 |
| NCAAF | 2018/09/15 19:00 | Mercer v Samford | L | 30-24 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | W | 21-18 |
| NCAAF | 2018/10/27 19:30 | East Tennessee State v Western Carolina | W | 45-43 |
| NCAAF | 2018/10/20 17:30 | Wofford v East Tennessee State | L | 30-17 |
| NCAAF | 2018/10/13 18:00 | East Tennessee State v The Citadel | W | 26-23 |
| NCAAF | 2018/10/06 19:30 | Gardner Webb v East Tennessee State | W | 0-45 |
| NCAAF | 2018/09/29 23:30 | Tennessee Chattanooga v East Tennessee State | W | 14-17 |
| NCAAF | 2018/09/22 23:30 | Furman v East Tennessee State | W | 27-29 |
| NCAAF | 2018/09/14 18:30 | East Tennessee State v VMI | W | 27-24 |